Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis
نویسندگان
چکیده
منابع مشابه
Differential ability of proinflammatory and anti-inflammatory macrophages to perform macropinocytosis
Macropinocytosis mediates the uptake of antigens and of nutrients that dictate the regulation of cell growth by mechanistic target of rapamycin complex 1 (mTORC1). Because these functions differ in proinflammatory and anti-inflammatory macrophages, we compared the macropinocytic ability of two extreme polarization states. We found that anti-inflammatory macrophages perform vigorous macropinocyt...
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The cellular movements that construct a macropinosome have a corresponding sequence of chemical transitions in the cup-shaped region of plasma membrane that becomes the macropinosome. To determine the relative positions of type I phosphatidylinositol 3-kinase (PI3K) and phospholipase C (PLC) in this pathway, we analyzed macropinocytosis in macrophages stimulated by the growth factor macrophage-...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2018
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e17-06-0419